Research
Research projects, publications, and scientific endeavors
Publications
DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins
Xu, L., Jin, S., Urem, M., Lee, S.-J., Lamers, M.H., Chen, X., Wolynes, P.G., Wuite, G.J.L.
Nature Communications (2025)
Mapping fast DNA polymerase exchange during replication
Xu, L., Halma, M.T.J., Wuite, G.J.L.
Nature Communications (2024)
Regulation of T7 Gp2.5 binding dynamics by its C-terminal tail, template conformation and sequence
Xu, L., Cabanas-Danés, J., Halma, M.T.J., Heller, I., Stratmann, S.A., van Oijen, A., Lee, S.-J., Peterman, E.J.G., Wuite, G.J.L.
Nucleic Acids Research (2023)
Unravelling how single-stranded DNA binding protein coordinates DNA metabolism using single-molecule approaches
Xu, L., Halma, M.T.J., Wuite, G.J.L.
International Journal of Molecular Sciences (2023)
Oxidized catechol-derived poly(ethylene glycol) for thiol-specific conjugation
Xu, L., Zhang, C., Wang, Q., Guo, F., Li, Z., Liu, Y., Su, Z.
Reactive and Functional Polymers (2017)
Purification and characterization of a long-acting ciliary neurotrophic factor via genetically fused with an albumin-binding domain
Xu, L., Zhang, C., Liu, L., Zhang, Y., Wang, Q., Wang, J., Liu, Y., Su, Z.
Protein Expression and Purification (2017)
Life under tension: the relevance of force on biological polymers
Halma, M.T.J., Xu, L.
Biophysics Reports (2024)
Past Projects
PhD&Postdoc @ VU Amsterdam, NL
Mapping fast DNA polymerase exchange during replication
Revealing autonomous exchange mechanisms in DNA replication
work
Single-stranded DNA-binding Protein Displacement During Replication
Investigating how DNA polymerase displaces protective SSB proteins using single-molecule biophysics
work
T7 Gp2.5 Binding Dynamics and Regulation
Single-molecule investigation of how T7 SSB protein binding is regulated by its C-terminal tail