Presented at SMBio25 West in Palo Alto, CA, sharing how I developed C-DAM (Correlated Dynamics and Activity Mapping) technology and its application in discovering DNA polymerase exchange dynamics and SSB displacement mechanisms.
News & Announcements
Latest updates from my research and academic journey
Attended the Damon Runyon Annual Retreat in Boston and presented my postdoctoral research on viral DNA packaging motors, connecting with Fellows from leading institutions across diverse cancer research areas.
Our paper on DNA polymerase actively displacing single-stranded DNA-binding proteins during replication has been published in Nature Communications! Using single-molecule studies and MD simulations, we revealed how DNA polymerase coordinates with SSBs to ensure efficient replication.
Excited to be awarded the prestigious Damon Runyon Fellowship and been named as HHMI-Damon Runyon Fellow at UC Berkeley!
Excited to join Prof. Carlos Bustamante's lab at UC Berkeley/HHMI to study viral DNA packaging motors!
Our paper on DNA polymerase exchange during replication has been published in Nature Communications! Featured in The-Scientist and BioArt.
Excited to defend my PhD thesis! Congrats Dr. Xu.
Our paper is online in Nucleic Acids Research about bacteriophage T7 single-stranded DNA-binding protein (gp2.5) dynamics! We directly visualized T7 gp2.5 binding to ssDNA at the single-molecule level, showing how it reduces DNA contour length and suppresses secondary structure formation in a force-dependent manner.