I'm a biophysicist studying viral DNA replication and packaging with single-molecule approaches. My goal is to understand how viruses replicate their genomes and package them into capsids—fundamental processes that could lead to new therapeutic targets. I'm also building SciXchange — a Scientific Materials Exchange Network to make collaborative research more efficient.

"Dream big, act little."

Currently, I am a Damon Runyon Fellow and postdoctoral researcher in Professor Carlos J. Bustamante's laboratory at UC Berkeley/HHMI. My work focuses on how ATPase motors translocate viral genomes into preassembled capsids using single-molecule biophysics techniques.

Previously, I completed my PhD in Professor Gijs Wuite's laboratory at Vrije Universiteit Amsterdam, where I developed C-DAM (Correlated force-fluorescence microscopy Dynamics and Activity Mapping) and used those techniques to understand DNA replication.

Research Themes

DNA Replication Dynamics

Understanding how DNA polymerases exchange during replication using single-molecule approaches

Viral DNA Packaging

Investigating how ATPase motors package viral genomes into capsids with force spectroscopy

Methodology

Developing correlative optical tweezers and fluorescence techniques for fundamental biological question

Research Interests

  • Single-molecule biophysics
  • DNA–protein interactions in nucleic acid metabolism
  • Development and application of single-molecule methodologies
  • Single-molecule pharmacology
  • AI 4 biomed
Longfu Xu

QB3 Institute & Department of Physics

UC Berkeley/HHMI

Berkeley, CA 94720, USA

Latest Updates

August 12, 2025
Our paper on DNA polymerase actively displacing single-stranded DNA-binding proteins during replication has been published in Nature Communications! Using single-molecule studies and MD simulations, we revealed how DNA polymerase coordinates with SSBs to ensure efficient replication.
May 18, 2025
Excited to be awarded the prestigious Damon Runyon Fellowship and been named as HHMI-Damon Runyon Fellow at UC Berkeley!
January 13, 2025
Excited to join Prof. Carlos Bustamante's lab at UC Berkeley/HHMI to study viral DNA packaging motors!

SciXchange

Scientific Materials Exchange Network

Building a trusted platform for researchers to share materials, reducing duplication and accelerating discovery. Currently in development.

Learn More

"Unraveling the mysteries of life, one molecule at a time."